China’s poultry farming accounts for 50% of the world’s poultry population, with about 17 billion birds slaughtered annually. In the livestock and poultry farming industry, the prevention and control of epidemics is always a top priority. Avian influenza and Newcastle disease are the “top killers” in the global poultry farming industry. Newcastle disease, as a serious threat to the health of poultry, has long brought substantial economic losses to farmers. The successful research and development of the Newcastle Disease Gene VII vaccine has forged a solid defense for the prevention and control of poultry disease and has become the dawn of the healthy development of the poultry farming industry.
With the continuous evolution of the Newcastle disease virus, the genotype VII strain has become the primary epidemic strain in recent years. It spreads fast and is highly pathogenic, and the control effect of traditional vaccines is not good. Once the poultry is infected with Newcastle disease, there will be dyspnea, diarrhea, neurological disorders, laying hens egg production decreasing significantly, young poultry mortality being very high, and so on, seriously affecting breeding efficiency. The Newcastle disease Genotype VII marker vaccine has been developed in response to this critical situation. The vaccine has excellent immunity against genotype VII Newcastle disease virus.
WIXBIO is collaborating with China’s most senior poultry research institute to launch the Newcastle disease Gene-VII marker inactivated vaccine. The vaccine has been licensed for sale in China and has received excellent customer feedback.
The technologies adopted in developing this vaccine:
1. Reverse Vaccinology technology platform
2.Homo-genotypic Vaccine
3. ND Negative Marker Vaccine and its accompanying diagnostic reagents
Highlights of the development of a marker vaccine for Newcastle disease:
- The vaccine’s characteristics are low toxicity, high efficiency, antigen matching, genetic stability, unique markers, and excellent growth performance.
- Characteristics of vaccine: good immune response, reduced detoxification, high protection efficiency.
- Supporting test products: simple, sensitive, high-throughput, can distinguish between serum antibodies induced by Newcastle Disease VII labeled vaccine strain and other Newcastle Disease strains.
- Decontaminate and assessable: through the technical solution, it can purify the epidemics in the Newcastle disease virus epidemic areas, reduce the use of related vaccines and veterinary drugs, and reduce the cost of feeding.
The antibodies produced by SPF chickens after immunization with the Newcastle disease type VII marker inactivated vaccine using the minimum and the conventional immunization doses were higher than those in the La Sota group.
The detection rate of Newcastle disease type VII marker inactivated vaccine in the excretion of virus was lower than that of La Sota.
The detection rate of the ND virus in organs of the group vaccinated with the inactivated vaccine of the VII type marker of the ND gene was lower than that of the La Sota group.
WIXBIO has obtained the international market agency right of Newcastle Disease Gene VII Labeled Inactivated Vaccine and the international market promotion and sales right of Newcastle Disease Gene VII Labeled Inactivated Vaccine production technology.WIXBIO is willing to work with global animal vaccine partners to prevent and control animal epidemics and share the best quality animal protection products and disease solutions.
The cooperation modes are as follows:
Exclusive agency: WIXBIO signs an exclusive agency agreement with the distributor in the fixed distribution area. The distributor with the agency right is responsible for completing the registration of the Newcastle disease Gene-VII marked inactivated vaccine in its agent country and forming sales after obtaining the registration certificate.
Technical cooperation: This plan applies to animal vaccine manufacturers. After signing the agreement, the property owner of Newcastle Disease Gene-VII labeled inactivated vaccine production technology will provide training and guidance to the partners on all relevant technologies, such as research and development, production, and quality inspection of the vaccine until the partners produce qualified products.
Clean up the Newcastle disease virus and create an epidemic-free zone: All parties sign an agreement, give full play to the advantages of official policies, strive for the financial support of government projects, build an inter-governmental cooperation project, establish an epidemic-free zone or farm by using the vaccines and technical solutions of the property owner, and establish a standard of epidemic free zone or farm through WHO certification and local official certification.
Recent progress in the development of Newcastle disease type VII marker vaccine series:
- Creation of live attenuated marker vaccine for Newcastle Disease (ND) gene type VII.
- Research and development of inactivated inactivated gene VII marker vaccine for Newcastle Disease
- Application technology of Newcastle disease gene VII marker vaccine and other products in disease purification.
